The KRAS/HRAS/NRAS Rabbit Monoclonal Antibody (CAB19779) is a powerful tool for researchers studying the KRAS, HRAS, and NRAS proteins, which are key players in cell signaling pathways involved in cell growth, proliferation, and survival. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting these Ras isoforms in human samples, making it an ideal choice for Western blot applications.The KRAS/HRAS/NRAS Rabbit Monoclonal Antibody binds specifically to the KRAS, HRAS, and NRAS proteins, allowing for precise detection and analysis in a variety of cell types.
This makes it an invaluable resource for investigations into cancer biology, where mutations in these Ras isoforms are frequently implicated in tumor development and progression.By gaining a better understanding of the role that KRAS, HRAS, and NRAS play in cellular signaling, researchers can uncover potential therapeutic targets for treating cancers driven by dysregulated Ras signaling pathways. The KRAS/HRAS/NRAS Rabbit Monoclonal Antibody is a valuable tool for advancing our knowledge of these important proteins and their impact on cancer biology.
Product Name:
KRAS+HRAS+NRAS Rabbit Monoclonal Antibody
SKU:
CAB19779
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-188 of human NRAS (P01111).
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Purification Method:
Affinity purification
Gene ID:
4893/3265/3845
Clone Number:
ARC2369
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using KRAS+HRAS+NRAS Rabbit mAb (CAB19779) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
