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NRAS Monoclonal Antibody [PAT2G9AT] (CPAB0444)

SKU:
CPAB0444
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT2G9AT
Applications:
WB
ELISA
$179
Frequently bought together:

Description

system_update_alt Datasheet

NRAS Monoclonal Antibody [PAT2G9AT] (CPAB0444)

The NRAS Monoclonal Antibody (CPAB0444) is a versatile tool for research involving NRAS, a key signaling molecule in cancer and other diseases. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting NRAS in human samples, making it an ideal choice for Western blot and immunohistochemistry applications.NRAS is a member of the RAS family of proteins and is involved in regulating cell growth, differentiation, and survival. Mutations in NRAS have been implicated in various cancers, making it a potential target for therapeutic intervention.

The NRAS Monoclonal Antibody enables researchers to study the expression and activity of NRAS in different cell types and tissues, providing valuable insights into the molecular mechanisms underlying cancer progression and drug resistance.By using the NRAS Monoclonal Antibody in their experiments, scientists can further elucidate the role of NRAS in cancer biology and potentially identify novel therapeutic strategies for targeting NRAS-driven cancers. This antibody is a valuable tool for researchers studying oncology, molecular biology, and drug discovery.

Product Name:NRAS Antibody
Product Sku:CPAB0444
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NRAS mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NRAS amino acids 1-186 purified from Ecoli.
Clone:PAT2G9AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:NRAS antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2a
Background:NRAS binds GDP/GTP and has intrinsic GTPase activity. NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This transport is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. NRAS is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this NRAS gene result in juvenile myelomonocytic leukemia.
Synonyms:GTPase NRas, HRAS1, ALPS4, N-ras, NRAS1, NS6, Transforming protein N-Ras.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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