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NR4A3 Antibody (PACO05394)

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SKU:
PACO05394
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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NR4A3 Antibody (PACO05394)

The NR4A3 Polyclonal Antibody (PACO05394) is a valuable tool for researchers studying NR4A3, a nuclear receptor gene that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications.NR4A3, also known as NOR-1, is a transcription factor that regulates the expression of genes involved in a wide range of physiological and pathological processes, making it an attractive target for research in fields such as cancer biology, cardiovascular diseases, and metabolic disorders.

By targeting NR4A3, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic strategies.The NR4A3 Polyclonal Antibody allows for the detection and analysis of NR4A3 protein levels in various cell types, providing researchers with a powerful tool for investigating the function of this nuclear receptor in different biological contexts. Its high reactivity and specificity make it an essential reagent for studies aimed at elucidating the role of NR4A3 in health and disease.

Antibody Name:NR4A3 Antibody (PACO05394)
Antibody SKU:PACO05394
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:Synthesized peptide derived from the Internal region of human NOR-1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:NR4A3; CHN; CSMF; MINOR; NOR1; TEC; Nuclear receptor subfamily 4 group A member 3; Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1
UniProt Protein Function:NR4A3: Binds to the B1A response-element. Defects in NR4A3 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving NR4A3 is found in patients with Erwing sarcoma. Translocation t(9;22)(q22-31;q11-12) with EWSR1. A chromosomal aberration involving NR4A3 is a cause of a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with TAF2N. Belongs to the nuclear hormone receptor family. NR4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Nuclear receptor; DNA-binding; OncoproteinChromosomal Location of Human Ortholog: 9q22Cellular Component: nucleoplasmMolecular Function: protein binding; protein homodimerization activity; protein kinase binding; thyroid hormone receptor activityBiological Process: cellular respiration; fat cell differentiation; gastrulation; mast cell degranulation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation; positive regulation of fatty acid oxidation; positive regulation of mast cell cytokine production; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; pyruvate oxidation; regulation of smooth muscle cell proliferation; transcription initiation from RNA polymerase II promoterDisease: Chondrosarcoma, Extraskeletal Myxoid
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
UniProt Code:Q92570
NCBI GenInfo Identifier:90110039
NCBI Gene ID:8013
NCBI Accession:Q92570.3
UniProt Secondary Accession:Q92570,Q12935, Q14979, Q16420, Q4VXA8, Q4VXA9, Q9UEK2 Q9UEK3, A2A3I7
UniProt Related Accession:Q92570
Molecular Weight:69,502 Da
NCBI Full Name:Nuclear receptor subfamily 4 group A member 3
NCBI Synonym Full Names:nuclear receptor subfamily 4 group A member 3
NCBI Official Symbol:NR4A3  
NCBI Official Synonym Symbols:CHN; TEC; CSMF; NOR1; MINOR  
NCBI Protein Information:nuclear receptor subfamily 4 group A member 3
UniProt Protein Name:Nuclear receptor subfamily 4 group A member 3
UniProt Synonym Protein Names:Mitogen-induced nuclear orphan receptor; Neuron-derived orphan receptor 1; Nuclear hormone receptor NOR-1
Protein Family:Nuclear receptor subfamily
UniProt Gene Name:NR4A3  
UniProt Entry Name:NR4A3_HUMAN

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