The NR4A2 Polyclonal Antibody is a valuable tool for researchers studying the NR4A2 protein, a transcription factor involved in various cellular processes including apoptosis, inflammation, and metabolism. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the NR4A2 protein, researchers can investigate its role in cell signaling pathways and its potential as a therapeutic target in diseases such as Parkinson's disease, cancer, and metabolic disorders.
NR4A2, also known as Nurr1, is a critical regulator of neuronal development and function, making it a key player in neurodegenerative disorders like Parkinson's disease. Its role in promoting cell survival and protecting against neurotoxicity highlights its potential as a target for neuroprotective therapies. By studying the function of NR4A2 using this antibody, researchers can gain insights into the molecular mechanisms underlying these diseases and facilitate the development of novel treatment strategies.
Product Name:
NR4A2 Polyclonal Antibody
SKU:
CAB22011
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 90-170 of human NR4A2 (NP_006177.1).
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
4929
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Raji, using NR4A2 Rabbit pAb (CAB22011) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
