The NR4A1 Polyclonal Antibody (CAB13316) is a crucial tool for researchers studying NR4A1, a nuclear receptor protein involved in various cellular processes such as inflammation, apoptosis, and cell proliferation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot applications. By targeting the NR4A1 protein, this antibody enables the detection and analysis of NR4A1 expression in different cell types, providing valuable insights for studies in immunology and cancer research.
NR4A1, also known as Nur77, is a transcription factor that plays a key role in regulating gene expression in response to diverse external stimuli. Its involvement in immune responses, cell survival, and metabolic pathways highlights its importance in understanding various diseases, including cancer and inflammatory disorders. By elucidating the function of NR4A1, researchers can uncover potential therapeutic targets for treating these conditions and developing personalized medicine approaches.
Product Name:
NUR77 Polyclonal Antibody
SKU:
CAB13316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human NUR77 (NP_002126.2).
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3164
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NUR77 antibody (CAB13316) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
