The NR3C2 Polyclonal Antibody (CAB3308) is a valuable tool for researchers investigating NR3C2, a nuclear receptor protein involved in regulating gene expression in response to hormones like cortisol. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting NR3C2 in human samples, particularly in Western blot experiments.NR3C2, also known as mineralocorticoid receptor, plays a crucial role in mediating the effects of aldosterone, a hormone that regulates electrolyte balance and blood pressure. Dysregulation of NR3C2 has been implicated in various diseases, including hypertension, cardiovascular disorders, and metabolic syndrome.
By targeting NR3C2, researchers can gain insights into the molecular mechanisms underlying these conditions and develop potential therapeutic strategies.The NR3C2 Polyclonal Antibody (CAB3308) offers a reliable means of studying NR3C2 expression and function in different cell types and tissues, making it a valuable tool for investigations in endocrinology, cardiovascular research, and drug development. Its versatility and specificity make it a valuable resource for advancing our understanding of NR3C2 biology and its implications for human health.
Product Name:
NR3C2 Rabbit Polyclonal Antibody
SKU:
CAB3308
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2) (NP_000892.2).
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4306
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Mineralocorticoid receptor (NR3C2) Rabbit pAb (CAB3308) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
