NR3C2 Rabbit Polyclonal Antibody (CAB3308)
- SKU:
- CAB3308
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | NR3C2 Rabbit Polyclonal Antibody |
SKU: | CAB3308 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 450-600 of human Mineralocorticoid receptor (NR3C2) (NP_000892.2). |
Sequence: | FPFM DGSY FSFM DDKD YYSL SGIL GPPV PGFD GNCE GSGF PVGI KQEP DDGS YYPE ASIP SSAI VGVN SGGQ SFHY RIGA QGTI SLSR SARD QSFQ HLSS FPPV NTLV ESWK SHGD LSSR RSDG YPVL EYIP ENVS SSTL RSVS TGSS RPS |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | MR; MCR; MLR; NR3C2VIT; Mineralocorticoid receptor (NR3C2) |
Positive Sample: | HeLa,293T,Mouse liver,Mouse kidney,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Endoplasmic reticulum membrane, Nucleus, Peripheral membrane protein. |
Calculated MW: | 107kDa |
Observed MW: | 100kDa |
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 4306 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |