The NR2E1 Polyclonal Antibody (CAB7455) is specially designed for research involving NR2E1, a nuclear receptor protein known for its role in regulating gene expression and cell differentiation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the NR2E1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent tool for studies in developmental biology, neurobiology, and cancer research.
NR2E1, also known as the tailless homolog 2 (TLX), is a key player in embryonic development, neural stem cell maintenance, and tumorigenesis. Its intricate regulatory functions in cell fate determination and proliferation make it a crucial target for investigations into neurological disorders, brain tumors, and developmental abnormalities. Understanding the mechanisms by which NR2E1 operates is essential for unraveling its therapeutic potential in these disease contexts.
Product Name:
NR2E1/TLX Rabbit Polyclonal Antibody
SKU:
CAB7455
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 106-385 of human NR2E1/TLX (NP_003260.1).
The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7101
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from U-251MG cells, using NR2E1/TLX Rabbit pAb (CAB7455) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
