The NR2C1 Polyclonal Antibody (CAB6675) is a valuable tool for researchers studying NR2C1, a nuclear receptor protein involved in various cellular processes, including gene regulation and development. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications. By selectively binding to NR2C1, the antibody allows for accurate detection and analysis of the protein in diverse cell types, making it ideal for investigations in molecular biology and developmental biology.
NR2C1, also known as testicular receptor 2 (TR2), plays a crucial role in regulating gene expression and controlling cell growth and differentiation. Its involvement in these fundamental biological processes underscores its importance as a potential target for research on diseases such as cancer, reproductive disorders, and metabolic diseases. Understanding the functions of NR2C1 is essential for unraveling its molecular mechanisms and exploring its therapeutic potential in various pathological conditions.
Product Name:
NR2C1 Rabbit Polyclonal Antibody
SKU:
CAB6675
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human NR2C1 (NP_003288.2).
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
7181
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Mouse testis, using NR2C1 antibody (CAB6675) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
