The NR1H4 Polyclonal Antibody (CAB12788) is a valuable tool for researchers studying the nuclear receptor subfamily 1 group H member 4 (NR1H4), also known as farnesoid X receptor (FXR). This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for experiments involving FXR detection and analysis.FXR is a key regulator of bile acid metabolism and has been implicated in various metabolic diseases, including cholestasis, fatty liver disease, and diabetes.
By targeting FXR, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.With its high specificity and reliability in Western blot applications, the NR1H4 Polyclonal Antibody is a valuable tool for unraveling the complex roles of FXR in metabolic disorders and paving the way for new treatments and interventions.
Product Name:
NR1H4 Rabbit Polyclonal Antibody
SKU:
CAB12788
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human NR1H4 (NP_001193922.1).
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
9971
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of Rat liver, using NR1H4 Rabbit pAb (CAB12788) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
