The NR1H2 Polyclonal Antibody (CAB16291) is a valuable tool for researchers studying NR1H2, a nuclear receptor protein known to play a key role in lipid metabolism and inflammatory response regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity in detecting NR1H2 in human samples, making it well-suited for use in Western blot applications. By specifically binding to NR1H2, this antibody allows for the accurate detection and analysis of the protein in various cell types, facilitating investigation in fields such as metabolic disorders, cardiovascular diseases, and inflammation. NR1H2, also known as liver X receptor beta (LXR-beta), is critical for maintaining lipid homeostasis and regulating genes involved in cholesterol metabolism and inflammatory pathways.
Its role in mediating lipid and inflammatory responses makes NR1H2 a significant target for research aimed at understanding and potentially modulating these processes in the context of metabolic diseases, atherosclerosis, and inflammation-related disorders. By elucidating the functions and mechanisms of NR1H2, researchers can gain valuable insights into the pathogenesis of various diseases and develop novel therapeutic strategies to target NR1H2-related pathways.
Product Name:
NR1H2 Rabbit Polyclonal Antibody
SKU:
CAB16291
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 180-260 of human LXR beta/NER (NP_009052.4).
Sequence:
QSQS PVGP QGSS SSAS GPGA SPGG SEAG SQGS GEGE GVQL TAAQ ELMI QQLV AAQL QCNK RSFS DQPK VTPW PLGA DPQS R
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
Purification Method:
Affinity purification
Gene ID:
7376
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NR1H2 Rabbit pAb (CAB16291) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
