NR1H2 Rabbit Polyclonal Antibody (CAB16291)
- SKU:
- CAB16291
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | NR1H2 Rabbit Polyclonal Antibody |
SKU: | CAB16291 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 180-260 of human LXR beta/NER (NP_009052.4). |
Sequence: | QSQS PVGP QGSS SSAS GPGA SPGG SEAG SQGS GEGE GVQL TAAQ ELMI QQLV AAQL QCNK RSFS DQPK VTPW PLGA DPQS R |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | NER; UNR; LXRB; LXR-b; NER-I; RIP15; NR1H2 |
Positive Sample: | HepG2,A-431,SH-SY5Y,Mouse liver,Mouse brain,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 51kDa |
Observed MW: | 51kDa |
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).
Purification Method: | Affinity purification |
Gene ID: | 7376 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |