The NR1D1 Polyclonal Antibody (CAB18602) is a high-quality research tool specifically designed for studying NR1D1, a nuclear receptor protein involved in circadian rhythm regulation and metabolism. This rabbit-derived antibody is highly specific and reactive with human samples, making it an ideal choice for Western blot applications.NR1D1, also known as Rev-erb alpha, plays a crucial role in the regulation of various biological processes, including the sleep-wake cycle, metabolism, and immune function. Dysregulation of NR1D1 has been implicated in metabolic disorders, cardiovascular disease, and cancer, making it a promising target for therapeutic intervention.
By using the NR1D1 Polyclonal Antibody, researchers can accurately detect and analyze NR1D1 protein levels in different cell types, providing valuable insights into its functions and potential therapeutic applications. This antibody is a valuable tool for studies in circadian biology, metabolism, and related fields, helping to advance our understanding of NR1D1's role in health and disease.
Product Name:
Rev-Erbα/NR1D1 Rabbit Polyclonal Antibody
SKU:
CAB18602
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-360 of human Rev-Erbα/NR1D1 (NP_068370.1).
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
Purification Method:
Affinity purification
Gene ID:
9572
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HepG2 cells, using Rev-Erbα/NR1D1 Rabbit pAb (CAB18602) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
