The NR0B1 Polyclonal Antibody (CAB1740) is a valuable tool for researchers studying NR0B1, a nuclear receptor that plays a key role in various biological processes, including development, metabolism, and reproduction. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.NR0B1, also known as DAX1, is a transcriptional regulator that can act as a co-repressor or co-activator, influencing the expression of genes involved in steroidogenesis and sexual differentiation. Dysregulation of NR0B1 is linked to disorders like adrenal hypoplasia congenita and hypogonadotropic hypogonadism, making it an important target for research in endocrinology and reproductive biology.
By detecting and analyzing NR0B1 protein expression in various cell types, researchers can gain insights into its function and signaling pathways, potentially leading to the development of novel therapeutic strategies for treating hormone-related disorders. The NR0B1 Polyclonal Antibody is a valuable tool for advancing our understanding of the complex roles of NR0B1 in health and disease.
Product Name:
NR0B1 Rabbit Polyclonal Antibody
SKU:
CAB1740
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human NR0B1 (NP_000466.2).
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Purification Method:
Affinity purification
Gene ID:
190
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NR0B1 Rabbit pAb (CAB1740) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
