The NQO2 Polyclonal Antibody (CAB11746) is a vital tool for researchers studying NQO2, an enzyme involved in cellular protection against oxidative stress and carcinogenesis. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting NQO2 in human samples, making it suitable for use in Western blotting applications. By targeting the NQO2 protein, researchers can accurately visualize and analyze its expression in different cell types, facilitating investigations in areas such as oxidative stress, cancer biology, and drug development.
NQO2, also known as NAD(P)H:quinone oxidoreductase 2, is a key player in cellular defense mechanisms against harmful reactive oxygen species and environmental toxins. Its role in maintaining cellular redox balance and detoxification processes underscores its importance in various disease conditions, including cancer, neurodegenerative disorders, and drug metabolism. By studying the functions of NQO2, researchers can gain insights into potential therapeutic strategies targeting oxidative stress-related pathologies and chemoresistance mechanisms.
Product Name:
NQO2 Rabbit Polyclonal Antibody
SKU:
CAB11746
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-231 of human NQO2 (NP_000895.2).
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4835
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NQO2 Rabbit pAb (CAB11746) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
