NQO1 Rabbit Polyclonal Antibody (CAB1518)
- SKU:
- CAB1518
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | NQO1 Rabbit Polyclonal Antibody |
SKU: | CAB1518 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-274 of human NQO1 (NP_000894.1). |
Sequence: | MVGR RALI VLAH SERT SFNY AMKE AAAA ALKK KGWE VVES DLYA MNFN PIIS RKDI TGKL KDPA NFQY PAES VLAY KEGH LSPD IVAE QKKL EAAD LVIF QFPL QWFG VPAI LKGW FERV FIGE FAYT YAAM YDKG PFRS KKAV LSIT TGGS GSMY SLQG IHGD MNVI LWPI QSGI LHFC GFQV LEPQ LTYS IGHT PADA RIQI LEGW KKRL ENIW DETP LYFA PSSL FDLN FQAG FLMK KEVQ DEEK NKKF GLSV GHHL GKSI PTDN QIKA RK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | DTD; QR1; DHQU; DIA4; NMOR1; NMORI; NQO1 |
Positive Sample: | HepG2,MCF7,NIH/3T3,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm. |
Calculated MW: | 31kDa |
Observed MW: | 31kDa |
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method: | Affinity purification |
Gene ID: | 1728 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |