The NPTX1 Polyclonal Antibody (PAC055102) is a valuable tool for researchers studying the neuronal pentraxin 1 (NPTX1) protein, which plays a role in synaptic plasticity and cognitive function. This antibody, produced in rabbits, is highly specific for human NPTX1 and has been validated for use in Western blot applications.NPTX1 is a secreted synaptic protein that is involved in the regulation of excitatory synapse function and plays a critical role in synaptic transmission and plasticity. Dysregulation of NPTX1 has been implicated in neurodegenerative disorders such as Alzheimer's disease, making it an important target for research in neuroscience and neurology.
By utilizing the NPTX1 Polyclonal Antibody, researchers can accurately detect and analyze NPTX1 protein levels in various cell types, providing valuable insights into its function and potential therapeutic implications. This antibody is a valuable tool for advancing our understanding of NPTX1 biology and its role in neurological disorders.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO55102 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO55102 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.
NPTX1: May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin.
UniProt Protein Details:
Protein type:Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Biological Process: central nervous system development; synaptic transmission; transport
NCBI Summary:
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
