The NPTX1 Polyclonal Antibody (PACO20124) is a valuable tool for researchers studying NPTX1, a protein involved in synaptic plasticity and neuronal development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the NPTX1 protein, this antibody enables the detection and analysis of NPTX1 in various cell types, making it ideal for studies in neuroscience and neurodegenerative diseases.
NPTX1, also known as neuronal pentraxin 1, plays a crucial role in the regulation of excitatory synapses and synaptic transmission. Its involvement in neuronal function and plasticity makes it a key target for investigating disorders such as Alzheimer's disease, schizophrenia, and epilepsy. By understanding the function of NPTX1, researchers can gain insight into the mechanisms underlying these conditions and develop potential therapeutic interventions targeting NPTX1.
Antibody Name:
NPTX1 Antibody (PACO20124)
Antibody SKU:
PACO20124
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human NPTX1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20124(NPTX1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO20124(NPTX1 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.
Synonyms:
neuronal pentraxin I
UniProt Protein Function:
NPTX1: May mediate uptake of degraded synaptic material which could play an important role in synaptic remodeling. Can mediate the neuronal and glial uptake of the snake venom toxin taipoxin.
UniProt Protein Details:
Protein type:Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Biological Process: central nervous system development; synaptic transmission; transport
NCBI Summary:
NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]
