The NPR3 Polyclonal Antibody (PAC028634) is a valuable tool for researchers studying NPR3, a cell surface receptor known for its role in regulating the activity of the hormone natriuretic peptide. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.NPR3, also known as the natriuretic peptide clearance receptor, plays a crucial role in the clearance of natriuretic peptides, which are key regulators of blood pressure and fluid balance. Dysregulation of NPR3 has been linked to various cardiovascular and renal disorders, making it a promising target for therapeutic interventions.
The NPR3 Polyclonal Antibody enables the detection and analysis of NPR3 protein in different cell types, providing researchers with a valuable tool for studying the function and regulation of this receptor. Its high specificity and sensitivity make it ideal for studies in cardiovascular biology, renal physiology, and drug development targeting the natriuretic peptide system.
Antibody Name:
Npr3 Antibody (PACO28634)
Antibody SKU:
PACO28634
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat Atrial natriuretic peptide receptor 3 protein (41-477AA)
Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity (By similarity).
ANP-C: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. Belongs to the ANF receptor family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Receptor, GPCRCellular Component: integral to plasma membrane; membrane; plasma membraneMolecular Function: adenylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; peptide receptor activity, G-protein coupled; protein homodimerization activityBiological Process: cAMP-mediated signaling; cyclic nucleotide biosynthetic process; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of adenylate cyclase activity; negative regulation of smooth muscle cell proliferation; pancreatic juice secretion; phosphoinositide-mediated signaling; positive regulation of nitric-oxide synthase activity; regulation of blood pressure; regulation of osteoblast proliferation; skeletal development
UniProt Protein Details:
NCBI Summary:
receptor for natriuretic peptide; may play role in hypertension and neurotransmitter efflux [RGD, Feb 2006]
