The NPR2 Polyclonal Antibody (CAB16061) is a valuable tool for researchers interested in studying NPR2, a key player in the regulation of cyclic guanosine monophosphate (cGMP) levels in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the NPR2 protein, this antibody allows for the detection and analysis of NPR2 in various cell types, making it an ideal choice for studies in cardiovascular biology, hypertension, and kidney function.NPR2, also known as natriuretic peptide receptor B, is a receptor that mediates the effects of atrial and brain natriuretic peptides on cGMP production.
Dysregulation of NPR2 has been implicated in various cardiovascular diseases, including hypertension and heart failure. Research into the role of NPR2 in these conditions is crucial for the development of targeted therapies that could ultimately improve patient outcomes.By utilizing the NPR2 Polyclonal Antibody, researchers can further understand the function of NPR2 and its impact on cGMP signaling pathways. This antibody provides a reliable tool for investigating the potential therapeutic benefits of targeting NPR2 in cardiovascular and renal disorders, ultimately advancing our knowledge of these important physiological processes.
Product Name:
ANPRB/NRP2 Rabbit Polyclonal Antibody
SKU:
CAB16061
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 130-320 of human ANPRB/NRP2 (NP_003986.2).
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
Purification Method:
Affinity purification
Gene ID:
4882
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using ANPRB/NRP2 Rabbit pAb (CAB16061) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
