NPR1 Rabbit Polyclonal Antibody (CAB10445)
- SKU:
- CAB10445
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | NPR1 Rabbit Polyclonal Antibody |
SKU: | CAB10445 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-470 of human NPR1 (NP_000897.3). |
Sequence: | EAGL CGED YVFF HLDI FGQS LQGG QGPA PRRP WERG DGQD VSAR QAFQ AAKI ITYK DPDN PEYL EFLK QLKH LAYE QFNF TMED GLVN TIPA SFHD GLLL YIQA VTET LAHG GTVT DGEN ITQR MWNR SFQG VTGY LKID SSGD RETD FSLW DMDP ENGA FRVV LNYN GTSQ ELVA VSGR KLNW PLGY PPPD IPKC GFDN EDPA CNQD HLS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ANPa; NPRA; ANPRA; GUC2A; GUCY2A; NPR1 |
Positive Sample: | 293T,HL-60,NCI-H460,HepG2,Mouse lung,Mouse liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Membrane, Single-pass type I membrane protein. |
Calculated MW: | 119kDa |
Observed MW: | 160kDa |
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).
Purification Method: | Affinity purification |
Gene ID: | 4881 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |