The NPPA Polyclonal Antibody (CAB1609) is specifically designed for research involving NPPA, a gene that encodes for a cardiac hormone known as atrial natriuretic peptide. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. By binding to the NPPA protein, this antibody enables the detection and analysis of NPPA in various cell types, particularly in studies related to cardiovascular disease and hypertension.Atrial natriuretic peptide is a hormone produced by the heart in response to stretching of the cardiac atria, and plays a crucial role in regulating blood pressure and fluid balance.
Research into NPPA can provide valuable insights into the pathophysiology of cardiovascular disorders such as heart failure, hypertension, and cardiac hypertrophy. By understanding the expression and function of NPPA, researchers can develop targeted therapies for these conditions, ultimately improving patient outcomes.
Product Name:
NPPA Rabbit Polyclonal Antibody
SKU:
CAB1609
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-151 of human NPPA (NP_006154.1).
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
4878
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NPPA Rabbit pAb (CAB1609) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
