The NPPA Polyclonal Antibody (CAB14755) is a valuable tool for researchers studying Natriuretic Peptide A (NPPA), a protein involved in regulating blood pressure and fluid balance in the body. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in various research applications, including Western blotting.NPPA, also known as Atrial Natriuretic Peptide (ANP), is a hormone produced by the heart in response to elevated blood pressure. It plays a key role in the maintenance of cardiovascular homeostasis, promoting vasodilation and diuresis to reduce blood volume and pressure.
Dysregulation of NPPA has been implicated in conditions such as hypertension, heart failure, and kidney disease, making it a promising target for therapeutic intervention.By utilizing the NPPA Polyclonal Antibody, researchers can accurately detect and measure NPPA levels in different biological samples, providing valuable insights into the role of this hormone in cardiovascular physiology and pathophysiology. This antibody is a valuable tool for investigations into the mechanisms underlying cardiovascular diseases and the development of novel treatments targeting NPPA signaling pathways.
Product Name:
NPPA Rabbit Polyclonal Antibody
SKU:
CAB14755
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NPPA (NP_006163.1).
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. This gene is located adjacent to another member of the natriuretic family of peptides on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
4878
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using NPPA Rabbit pAb (CAB14755) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
