The NPM2 Polyclonal Antibody (PAC037458) is a valuable tool for research involving NPM2, a nucleoplasmin family member involved in chromatin remodeling and cell cycle regulation. This antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.NPM2, also known as nucleophosmin 2, is essential for maintaining genomic stability and proper cell division. Its role in the cell cycle and chromatin structure makes it a key player in processes like DNA replication and repair.
By targeting NPM2 with this antibody, researchers can study its localization and function in different cell types, shedding light on its involvement in cancer development and other diseases.Furthermore, understanding the molecular mechanisms of NPM2 can provide insights into potential therapeutic strategies for cancer treatment and other conditions related to cell proliferation and genomic instability. This antibody is a valuable asset for scientists investigating the intricate roles of NPM2 in cellular processes and disease pathways.
Antibody Name:
NPM2 Antibody (PACO37458)
Antibody SKU:
PACO37458
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Nucleoplasmin-2 protein (1-136AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO37458 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37458 at dilution of 1:100.
Background:
Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.
Synonyms:
Nucleoplasmin-2, NPM2
UniProt Protein Function:
NPM2: Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization. Belongs to the nucleoplasmin family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 8p21.3Cellular Component: nuclear chromatin; nucleusMolecular Function: enzyme binding; nucleic acid binding; histone binding; chromatin bindingBiological Process: chromatin remodeling; positive regulation of catalytic activity; embryonic development; positive regulation of meiosis; single fertilization; regulation of exit from mitosis; oocyte differentiation; protein homooligomerization; positive regulation of DNA replication
