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NPM1 Rabbit Polyclonal Antibody (CAB17983)

SKU:
CAB17983
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:NPM1 Rabbit Polyclonal Antibody
SKU:CAB17983
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 9-122 of human NPM1 (NP_002511.1).
Sequence:MSPL RPQN YLFG CELK ADKD YHFK VDND ENEH QLSL RTVS LGAG AKDE LHIV EAEA MNYE GSPI KVTL ATLK MSVQ PTVS LGGF EITP PVVL RLKC GSGP VHIS GQHL VAVE ED
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:B23; NPM; NPM1
Positive Sample:293T,Jurkat,HeLa,NIH/3T3,Mouse thymus,Mouse spleen
Cellular Localization:Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus, nucleoplasm.
Calculated MW:33kDa
Observed MW:38kDa

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified.

Purification Method:Affinity purification
Gene ID:4869
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using NPM1 Rabbit pAb (CAB17983) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.

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