NPM1 Rabbit Polyclonal Antibody (CAB17983)
- SKU:
- CAB17983
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | NPM1 Rabbit Polyclonal Antibody |
SKU: | CAB17983 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 9-122 of human NPM1 (NP_002511.1). |
Sequence: | MSPL RPQN YLFG CELK ADKD YHFK VDND ENEH QLSL RTVS LGAG AKDE LHIV EAEA MNYE GSPI KVTL ATLK MSVQ PTVS LGGF EITP PVVL RLKC GSGP VHIS GQHL VAVE ED |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | B23; NPM; NPM1 |
Positive Sample: | 293T,Jurkat,HeLa,NIH/3T3,Mouse thymus,Mouse spleen |
Cellular Localization: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus, nucleoplasm. |
Calculated MW: | 33kDa |
Observed MW: | 38kDa |
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified.
Purification Method: | Affinity purification |
Gene ID: | 4869 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |