The NPHS2 Polyclonal Antibody (CAB17337) is a valuable tool for researchers studying NPHS2, a key protein involved in kidney function and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By selectively binding to NPHS2, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in nephrology and renal diseases.NPHS2, also known as podocin, is a crucial component of the kidney filtration barrier and plays a significant role in maintaining normal kidney function. Mutations in the NPHS2 gene have been linked to hereditary nephrotic syndrome, a severe kidney disorder characterized by proteinuria and edema.
Research into the function and regulation of NPHS2 is essential for understanding the pathogenesis of kidney diseases and developing targeted therapies for patients affected by these conditions.Overall, the NPHS2 Polyclonal Antibody (CAB17337) serves as a reliable tool for researchers investigating the role of NPHS2 in kidney biology and disease. Its specificity and sensitivity make it an indispensable asset for advancing our understanding of renal disorders and developing novel treatment strategies.
Product Name:
NPHS2 Rabbit Polyclonal Antibody
SKU:
CAB17337
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-388 of human NPHS2 (NP_055440.1).
cell-cell junction, cytoplasmic side of plasma membrane, endoplasmic reticulum, extracellular exosome, plasma membrane, slit diaphragm
Calculated MW:
42kDa
Observed MW:
42kDa
This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7827
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NPHS2 antibody (CAB17337) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
