The NPC2 Polyclonal Antibody (CAB5413) offered by AssayGenie is a valuable tool for researchers studying NPC2, a protein involved in cholesterol transport and regulation. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including Western blot and immunofluorescence.NPC2 plays a crucial role in intracellular cholesterol trafficking and mutations in the NPC2 gene have been linked to Niemann-Pick disease type C2, a rare lysosomal storage disorder. By using the NPC2 Polyclonal Antibody, researchers can study the expression and localization of NPC2 in different cell types and tissues, shedding light on its function in cholesterol metabolism and potential implications in disease.
With its high reactivity and specificity, the NPC2 Polyclonal Antibody is a valuable tool for investigating NPC2 biology and its role in cholesterol homeostasis. This antibody is an essential addition to any lab conducting research in lipid metabolism, lysosomal storage disorders, or related fields.
Product Name:
NPC2 Rabbit Polyclonal Antibody
SKU:
CAB5413
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-151 of human NPC2 (NP_006423.1).
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy.
Purification Method:
Affinity purification
Gene ID:
10577
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse lung, using NPC2 Rabbit pAb (CAB5413) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
