NPC1L1 Rabbit Polyclonal Antibody (CAB10049)
- SKU:
- CAB10049
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | NPC1L1 Rabbit Polyclonal Antibody |
SKU: | CAB10049 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1030-1100 of human Niemann-Pick type C1 Like-1 (NP_001095118.1). |
Sequence: | AAYS TSVN LTSD GQVL ASRF MAYH KPLK NSQD YTEA LRAA RELA ANIT ADLR KVPG TDPA FEVF PYTI TNV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | LDLCQ7; NPC11L1; SLC65A2; Niemann-Pick type C1 Like-1 |
Positive Sample: | HepG2 |
Conjugate: | Unconjugated |
Cellular Localization: | Apical cell membrane, Cell membrane, Cytoplasmic vesicle membrane, Multi-pass membrane protein. |
Calculated MW: | 149kDa |
Observed MW: | 140kDa/150kDa |
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 29881 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |