The NPBWR2 Polyclonal Antibody (PACO28606) is a valuable tool for researchers studying the Neuropeptide B/W receptor 2 (NPBWR2), a G protein-coupled receptor involved in various physiological processes including modulation of pain, stress response, and energy homeostasis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to NPBWR2, this antibody allows for the detection and analysis of the receptor in different cell types, making it ideal for studies in neurobiology and endocrinology.
NPBWR2, also known as GPR7, is a promising target for research into conditions such as chronic pain, anxiety disorders, and metabolic disorders. Understanding the role of NPBWR2 in these processes is essential for the development of novel therapeutics aimed at modulating its activity for therapeutic benefit. By utilizing the NPBWR2 Polyclonal Antibody, researchers can further uncover the complex mechanisms by which NPBWR2 influences physiological functions, opening new avenues for potential therapeutic interventions.
Antibody Name:
NPBWR2 Antibody (PACO28606)
Antibody SKU:
PACO28606
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Neuropeptides B/W receptor type 2 protein (1-45AA)
Immunofluorescent analysis of A549 cells using PACO28606 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.
NPBWR2: Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Belongs to the G-protein coupled receptor 1 family.Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCRChromosomal Location of Human Ortholog: 20q13.3Cellular Component: integral to membrane; integral to plasma membrane; neuron projection; plasma membraneMolecular Function: neuropeptide binding; neuropeptide receptor activity; opioid receptor activity; protein bindingBiological Process: G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cyclic nucleotide second messenger; neuropeptide signaling pathway; synaptic transmission
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor. The encoded protein is similar in sequence to another G protein-coupled receptor (GPR7), and it is structurally similar to opioid and somatostatin receptors. This protein binds neuropeptides B and W. This gene is intronless and is expressed primarily in the frontal cortex of the brain. [provided by RefSeq, Jul 2008]
