The NPAS4 Antibody (PACO03852) is a polyclonal antibody specifically designed for research involving NPAS4, a transcription factor that plays a crucial role in neuronal development and function. This antibody, generated in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.NPAS4 is known for its involvement in regulating gene expression in response to neuronal activity, particularly in the development of inhibitory synapses and the maintenance of neural circuits. Its significance in neurobiology makes it a valuable target for studies in neuroscience, neurodevelopmental disorders, and neurodegenerative diseases.
By binding to NPAS4, this antibody allows for the detection and analysis of the protein in different cell types and tissues, providing researchers with a powerful tool for understanding the molecular mechanisms underlying neuronal development and function. With its applications in various research fields, the NPAS4 Antibody is an essential resource for advancing our knowledge of the nervous system and potential therapeutic interventions.
Antibody Name:
NPAS4 Antibody
Antibody SKU:
PACO03852
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human NPAS4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NPAS4; BHLHE79; NXF; PASD10; Neuronal PAS domain-containing protein 4; Neuronal PAS4; Class E basic helix-loop-helix protein 79; bHLHe79; HLH-PAS transcription factor NXF; PAS domain-containing protein 10
UniProt Protein Function:
NPAS4: Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 11q13Cellular Component: transcription factor complex; nucleusMolecular Function: signal transducer activity; protein heterodimerization activityBiological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction
UniProt Protein Details:
NCBI Summary:
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
