The CD300A Polyclonal Antibody (PAC034830) is a versatile tool for researchers studying the CD300A protein, an immune regulatory molecule known for inhibiting immune responses. This polyclonal antibody, manufactured in rabbits, exhibits high reactivity with human samples and is specifically validated for Western blot applications. By binding to the CD300A protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in immunology and cancer research.CD300A, also referred to as an immune inhibitory receptor, plays a crucial role in maintaining immune balance by regulating inflammation and suppressing allergic reactions.
Its importance in immune response modulation positions it as a valuable target for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of CD300A is essential for the development of therapies that can manipulate or leverage immune function in these disease contexts. Overall, the CD300A Polyclonal Antibody (PAC034830) is an indispensable tool for researchers seeking to unravel the intricacies of immune regulation and explore novel treatment strategies for a variety of diseases.
Antibody Name:
NP Antibody (PACO34830)
Antibody SKU:
PACO34830
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Influenza B virus
Immunogen:
Recombinant Influenza B virus Nucleoprotein protein (1-560AA)
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/β pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acid, fication of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus ().
