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NP Antibody (PACO34666)

SKU:
PACO34666
Product Type:
Antibody
Reactivity:
Virus - Influenza B
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$431

Description

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NP Antibody (PACO34666)

The NP Antibody (PACO34666) is a valuable tool for researchers investigating the role of NP (Nucleoprotein) in viral infection and immune response. This polyclonal antibody, produced by Assay Genie, is raised in rabbits and specifically targets the NP protein, a key component of many viruses including influenza.NP is essential for viral replication and transcription, making it a critical target for antiviral drug development and vaccine design.

The NP Antibody is highly reactive with human samples and has been validated for use in various applications, including immunofluorescence and ELISA.By using the NP Antibody, researchers can study the molecular mechanisms of viral infection, immune evasion, and host-pathogen interactions. This antibody is an essential tool for advancing our understanding of viral diseases and developing novel therapeutics to combat viral infections.

Antibody Name:NP Antibody (PACO34666)
Antibody SKU:PACO34666
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Influenza B virus
Immunogen:Recombinant Influenza B virus Nucleoprotein protein (1-168AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/β pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acid, fication of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus
Synonyms:Nucleoprotein (Nucleocapsid protein) (Protein N), NP
UniProt Protein Function:Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:P04666
NCBI GenInfo Identifier:139120
NCBI Gene ID:
NCBI Accession:P04666.1
UniProt Secondary Accession:P04666
UniProt Related Accession:P04666
Molecular Weight:20.8 kDa
NCBI Full Name:Nucleoprotein
NCBI Synonym Full Names:
NCBI Official Symbol:
NCBI Official Synonym Symbols:
NCBI Protein Information:
UniProt Protein Name:Nucleoprotein
UniProt Synonym Protein Names:Nucleocapsid protein; Protein N
Protein Family:Nucleoprotein
UniProt Gene Name:NP  
UniProt Entry Name:NCAP_INBSI

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