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NP Antibody (PACO34654)

SKU:
PACO34654
Product Type:
Antibody
Reactivity:
Virus - Influenza A
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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NP Antibody (PACO34654)

The NP Antibody (PACO34654) is a highly specific and sensitive tool for research involving the NP protein, a key component of the influenza virus. This polyclonal antibody, produced using state-of-the-art technology, is able to detect the NP protein in human samples and is validated for use in various applications, including Western blotting and immunofluorescence.The NP protein, essential for viral replication and transcription, is a target of interest for researchers studying influenza virus biology and pathogenesis. By using the NP Antibody, researchers can accurately detect and analyze the NP protein in infected cells, tissues, and biological fluids, allowing for a deeper understanding of the virus-host interactions and immune responses.

The NP Antibody is a valuable tool for studying influenza virus infections, antiviral drug development, and vaccine research. Its high specificity and sensitivity make it an ideal choice for scientists looking to advance their understanding of influenza virus biology and develop new strategies for controlling and preventing influenza outbreaks.

Antibody Name:NP Antibody (PACO34654)
Antibody SKU:PACO34654
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Influenza A virus
Immunogen:Recombinant Influenza A virus Nucleoprotein protein (1-498AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/β pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acid, fication of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Synonyms:Nucleoprotein (Nucleocapsid protein) (Protein N), NP
UniProt Protein Function:Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
UniProt Protein Details:
NCBI Summary:
UniProt Code:P03466
NCBI GenInfo Identifier:8486130
NCBI Gene ID:956531
NCBI Accession:NP_040982.1
UniProt Secondary Accession:P03466,Q20N34, Q58NB3, Q67228, Q80AB4
UniProt Related Accession:P03466,AAA43467
Molecular Weight:
NCBI Full Name:nucleocapsid protein
NCBI Synonym Full Names:
NCBI Official Symbol:NP  
NCBI Official Synonym Symbols:
NCBI Protein Information:nucleocapsid protein
UniProt Protein Name:Nucleoprotein
UniProt Synonym Protein Names:Nucleocapsid protein; Protein N
Protein Family:Nucleoprotein
UniProt Gene Name:NP  
UniProt Entry Name:NCAP_I34A1

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