The Noxa2 (p67phox) Rabbit Monoclonal Antibody (CAB3703) is an essential tool for researchers studying the Noxa2 protein, a component of the NADPH oxidase complex involved in the production of reactive oxygen species (ROS) in phagocytes. This antibody, developed using rabbit monoclonal technology, exhibits high specificity and sensitivity in detecting Noxa2 in human samples, making it ideal for use in various applications such as Western blotting.Noxa2, also known as p67phox, plays a crucial role in the innate immune response by promoting the assembly of the NADPH oxidase complex, which is vital for microbicidal activity in phagocytic cells. Dysregulation of Noxa2 activity has been implicated in various inflammatory and autoimmune diseases, as well as in the progression of cancer.
Therefore, studying the function and regulation of Noxa2 is essential for gaining insights into pathophysiological processes and for the development of targeted therapies.By using the Noxa2 (p67phox) Rabbit Monoclonal Antibody (CAB3703), researchers can accurately and reliably detect and quantify Noxa2 protein levels in biological samples, enabling further investigations into the role of Noxa2 in health and disease. This antibody is a valuable tool for researchers in the fields of immunology, inflammation, and cancer research.
Product Name:
NOXA2/p67phox Rabbit Monoclonal Antibody
SKU:
CAB3703
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-300 of human NOXA2/p67phox (P19878).
Sequence:
GKAT VVAS VVDQ DSFS GFAP LQPQ AAEP PPRP KTPE IFRA LEGE AHRV LFGF VPET KEEL QVMP GNIV FVLK KGND NWAT VMFN GQKG LVPC NYLE PVEL R
Tested Applications:
WBIHC-PELISA
Recommended Dilution:
WB,1:500 - 1:1000 IHC-P,1:50 - 1:200
Synonyms:
NCF-2; NOXA2; P67PHOX; P67-PHOX; NOXA2/p67phox
Positive Sample:
Mouse lung,Rat lung
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm
Calculated MW:
60kDa
Observed MW:
70kDa
This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4688
Clone Number:
ARC0828
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using NOXA2/p67phox Rabbit mAb (CAB3703) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
