The NOXA1 Polyclonal Antibody (CAB13844) is a powerful tool for researchers studying NOXA1, a critical component of the NADPH oxidase complex involved in reactive oxygen species (ROS) production. This antibody, raised in rabbits, is highly specific and validated for use in various applications, including Western blotting.NOXA1 is essential for the activation of the NAPDH oxidase complex, which plays a key role in the generation of ROS and the regulation of oxidative stress in cells. Dysregulation of ROS production has been implicated in various diseases, including cancer, cardiovascular diseases, and neurodegenerative disorders.
Therefore, understanding the function and regulation of NOXA1 is crucial for unraveling the complex mechanisms underlying these pathologies.The NOXA1 Polyclonal Antibody binds specifically to the NOXA1 protein, allowing for the accurate detection and analysis of NOXA1 levels in different cell types and tissues. Its high reactivity and specificity make it an ideal tool for researchers investigating the role of NOXA1 in oxidative stress, inflammation, and disease development. By studying NOXA1, researchers can gain valuable insights into potential therapeutic targets for diseases associated with ROS dysregulation.
Product Name:
NOXA1 Rabbit Polyclonal Antibody
SKU:
CAB13844
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 140-300 of human NOXA1 (NP_006638.1).
HepG2,HT-29,DU145,BxPC-3,Mouse small intestine,Mouse stomach,Mouse lung,Rat brain
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm.
Calculated MW:
51kDa
Observed MW:
50kDa
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
10811
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NOXA1 Rabbit pAb (CAB13844) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
