The NOX4 Polyclonal Antibody (CAB2201) is a valuable tool for researchers studying NOX4, a key enzyme involved in the production of reactive oxygen species (ROS) in cells. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It specifically binds to the NOX4 protein, allowing for accurate detection and analysis in a variety of cell types.NOX4 is known for its role in oxidative stress and has been implicated in a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative disorders.
By understanding the function of NOX4 and its impact on cellular processes, researchers can uncover new insights into disease mechanisms and potentially develop targeted therapies.The NOX4 Polyclonal Antibody is a valuable tool for investigating the role of NOX4 in health and disease, making it an essential reagent for studies in the fields of cell biology, cancer research, and oxidative stress.
Product Name:
NADPH oxidase 4 (NOX4) Polyclonal Antibody
SKU:
CAB2201
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 328-578 of human NADPH oxidase 4 (NOX4) (NP_058627.1).
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
50507
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NADPH oxidase 4 (NOX4) Rabbit pAb (CAB2201) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
