The NOVA1 Polyclonal Antibody (CAB12030) is a valuable tool for researchers studying the NOVA1 protein, which plays a crucial role in regulating alternative splicing in RNA processing. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.NOVA1 is a key player in the post-transcriptional control of gene expression, particularly in the brain where it regulates neuronal development and synaptic function. Dysregulation of NOVA1 has been implicated in neurological disorders such as epilepsy and cognitive impairments, making it a potential therapeutic target for these conditions.
By enabling the detection and analysis of NOVA1 in various cell types, this polyclonal antibody is ideal for studies in neuroscience, molecular biology, and developmental biology. Its specificity and sensitivity make it a valuable tool for investigating the role of NOVA1 in normal physiological processes and disease pathogenesis.
Product Name:
NOVA1 Rabbit Polyclonal Antibody
SKU:
CAB12030
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 408-507 of human NOVA1 (NP_002506.2).
This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
4857
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NOVA1 Rabbit pAb (CAB12030) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
