The NOTUM Polyclonal Antibody (CAB16600) is a valuable tool for researchers studying the NOTUM protein, which plays a critical role in Wnt signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NOTUM protein, this antibody allows for the detection and analysis of NOTUM in a variety of cell types, making it ideal for research in developmental biology, tissue regeneration, and cancer biology.NOTUM is an extracellular enzyme that regulates the activity of Wnt ligands by irreversibly deacylating them, thus influencing various cellular processes such as cell differentiation, proliferation, and migration.
Dysregulation of the Wnt signaling pathway, in which NOTUM is a key player, has been linked to a variety of diseases including cancer, developmental disorders, and neurodegenerative diseases. Therefore, the NOTUM Polyclonal Antibody is a valuable tool for understanding the role of NOTUM in these pathologies and may lead to the development of novel therapeutic strategies targeting the Wnt signaling pathway.
Product Name:
NOTUM Rabbit Polyclonal Antibody
SKU:
CAB16600
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human NOTUM (NP_848588.3).
Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region.
Purification Method:
Affinity purification
Gene ID:
147111
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NOTUM Rabbit pAb (CAB16600) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
