NOTCH3 Rabbit Polyclonal Antibody (CAB3115)
- SKU:
- CAB3115
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | NOTCH3 Rabbit Polyclonal Antibody |
SKU: | CAB3115 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1520-1640 of human NOTCH3 (NP_000426.2). |
Sequence: | PPEE LLRS SADF LQRL SAIL RTSL RFRL DAHG QAMV FPYH RPSP GSEP RARR ELAP EVIG SVVM LEID NRLC LQSP ENDH CFPD AQSA ADYL GALS AVER LDFP YPLR DVRG EPLE PPEP S |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | IMF2; LMNS; CASIL; CADASIL; CADASIL1; NOTCH3 |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 244kDa |
Observed MW: | 90kDa/280kDa |
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Purification Method: | Affinity purification |
Gene ID: | 4854 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |