NOTCH3 Rabbit Polyclonal Antibody (CAB13522)
- SKU:
- CAB13522
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | NOTCH3 Rabbit Polyclonal Antibody |
SKU: | CAB13522 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 2200-2321 of human NOTCH3 (NP_000426.2). |
Sequence: | TPVS PQER PPPY LAVP GHGE EYPA AGAH SSPP KARF LRVP SEHP YLTP SPES PEHW ASPS PPSL SDWS ESTP SPAT ATGA MATT TGAL PAQP LPLS VPSS LAQA QTQL GPQP EVTP KRQV LA |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 |
Synonyms: | IMF2; LMNS; CASIL; CADASIL; CADASIL1; NOTCH3 |
Positive Sample: | K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 244kDa |
Observed MW: | 90kDa |
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Purification Method: | Affinity purification |
Gene ID: | 4854 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |