The Notch2 Polyclonal Antibody is a powerful tool for researchers studying the Notch2 protein, a key regulator of cell development and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Notch2, researchers can accurately detect and analyze this important protein in various cell types.Notch2 is known for its role in directing cell fate decisions, particularly in the development of various tissues and organs. Dysregulation of Notch signaling has been implicated in a variety of diseases, including cancer, developmental disorders, and autoimmune conditions.
The ability to study Notch2 expression and activity using this antibody is crucial for advancing our understanding of these complex diseases and identifying potential therapeutic targets.With its high specificity and sensitivity, the Notch2 Polyclonal Antibody is an essential tool for researchers investigating Notch signaling pathways, cell fate determination, and the role of Notch2 in disease development. Its versatility and reliability make it an invaluable resource for studies in molecular biology, immunology, and cancer research.
Product Name:
NOTCH2 Polyclonal Antibody
SKU:
CAB24877
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 1697-1819 of human NOTCH2(NP_077719.2).
Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein.
Calculated MW:
265kDa
Observed MW:
110kDa
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4853
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen using NOTCH2 Rabbit pAb(CAB24877) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:10s.
