NOTCH2 Rabbit Polyclonal Antibody (CAB0560)
- SKU:
- CAB0560
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Description
Product Name: | NOTCH2 Rabbit Polyclonal Antibody |
SKU: | CAB0560 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 2242-2471 of human NOTCH2 (NP_077719.2). |
Sequence: | SRLH PVPV PADW MNRM EVNE TQYN EMFG MVLA PAEG THPG IAPQ SRPP EGKH ITTP REPL PPIV TFQL IPKG SIAQ PAGA PQPQ STCP PAVA GPLP TMYQ IPEM ARLP SVAF PTAM MPQQ DGQV AQTI LPAY HPFP ASVG KYPT PPSQ HSYA SSNA AERT PSHS GHLQ GEHP YLTP SPES PDQW SSSS PHSA SDWS DVTT SPTP GGAG GGQR GPGT HMSE PPHN NMQV YA |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | hN2; AGS2; HJCYS; NOTCH2 |
Positive Sample: | 293T,LO2,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 265kDa |
Observed MW: | 120kDa |
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4853 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |