notch1a Antibody (PACO54242)
- SKU:
- PACO54242
- Product Type:
- Antibody
- Reactivity:
- Fish - Zebrafish
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
notch1a Antibody (PACO54242)
The Notch1a Monoclonal Antibody (PAC054242) is a powerful tool for studying the Notch1a protein, a key regulator of cell signaling pathways. Notch1a is involved in various cellular processes, including cell fate determination, differentiation, and proliferation. This antibody, generated from hybridoma cells, specifically targets Notch1a in human samples and is validated for use in immunofluorescence and flow cytometry applications.Notch1a plays a crucial role in development and disease, with dysregulation of its signaling pathway implicated in cancer, cardiovascular disorders, and developmental abnormalities.
By targeting Notch1a, researchers can investigate its role in various cellular processes and potentially uncover new therapeutic targets for treating Notch1a-related diseases. This antibody is a valuable tool for studies in cell biology, developmental biology, and drug discovery related to Notch1a signaling.
| Antibody Name: | notch1a Antibody (PACO54242) |
| Antibody SKU: | PACO54242 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Zebrafish |
| Immunogen: | Recombinant Zebrafish Neurogenic locus notch homolog protein 1 protein (21-338AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (By similarity). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (By similarity). |
| Synonyms: | Neurogenic locus notch homolog protein 1 (Notch 1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)], notch1a, notch |
| UniProt Protein Function: | Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) (). |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P46530 |
| NCBI GenInfo Identifier: | 18859115 |
| NCBI Gene ID: | 30718 |
| NCBI Accession: | NP_571516.1 |
| UniProt Secondary Accession: | P46530 |
| UniProt Related Accession: | P46530 |
| Molecular Weight: | 262,308 Da |
| NCBI Full Name: | neurogenic locus notch homolog protein 1 |
| NCBI Synonym Full Names: | notch 1a |
| NCBI Official Symbol: | notch1a  |
| NCBI Official Synonym Symbols: | des; n1a; wu:fc01e02; wu:fc37a05Â Â |
| NCBI Protein Information: | neurogenic locus notch homolog protein 1 |
| UniProt Protein Name: | Neurogenic locus notch homolog protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | notch1a  |
| UniProt Entry Name: |
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