null

Nos3 Antibody (PACO33708)

SKU:
PACO33708
Product Type:
Antibody
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Nos3 Antibody (PACO33708)

The NOS3 Polyclonal Antibody (PAC033708) is a valuable tool for researchers studying NOS3, also known as nitric oxide synthase 3. NOS3 plays a crucial role in the production of nitric oxide, a key signaling molecule involved in various physiological processes such as vasodilation, neurotransmission, and immune response.This antibody, specifically raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the NOS3 protein, researchers can detect and analyze its expression in different cell types, providing insights into its role in cardiovascular health, neuronal signaling, and inflammation.

Given the importance of nitric oxide in regulating blood flow, neuronal communication, and immune function, the NOS3 Polyclonal Antibody is a valuable tool for studies in cardiovascular biology, neurobiology, and immunology. Its utility extends to research on conditions such as cardiovascular diseases, neurological disorders, and inflammatory conditions where dysregulation of nitric oxide signaling is implicated. Understanding the function of NOS3 can pave the way for the development of novel therapeutic strategies targeting nitric oxide pathways.

Antibody Name:Nos3 Antibody (PACO33708)
Antibody SKU:PACO33708
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Rat
Immunogen:Recombinant Rat Nitric oxide synthase, endothelial protein (519-690AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Synonyms:Nitric oxide synthase, endothelial (EC 1.14.13.39) (Constitutive NOS) (cNOS) (EC-NOS) (Endothelial NOS) (eNOS) (NOS type III) (NOSIII), Nos3
UniProt Protein Function:eNOS: endothelial constitutive nitric oxide synthase. Synthesizes nitric oxide (NO) from arginine and oxygen, which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Induced in humans by caloric restriction. Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN.
UniProt Protein Details:

Protein type:EC 1.14.13.39; Oxidoreductase; Amino Acid Metabolism - arginine and proline

Cellular Component: apical part of cell; caveola; cytoplasm; cytoskeleton; cytosol; Golgi apparatus; lipid raft; mitochondrion; nucleolus; nucleus; plasma membrane; sarcolemma; vesicle membrane

Molecular Function:actin binding; actin monomer binding; beta-catenin binding; cadherin binding; calmodulin binding; FAD binding; FMN binding; heme binding; Hsp90 protein binding; iron ion binding; NADP binding; nitric-oxide synthase activity; nitric-oxide synthase binding; protein binding

Biological Process: aging; angiogenesis; arginine catabolic process; blood vessel remodeling; endothelial cell migration; female pregnancy; in utero embryonic development; lipopolysaccharide-mediated signaling pathway; lung development; negative regulation of blood pressure; negative regulation of calcium ion transport; negative regulation of cell proliferation; negative regulation of hydrolase activity; negative regulation of muscle hyperplasia; negative regulation of potassium ion transport; negative regulation of smooth muscle cell proliferation; nitric oxide biosynthetic process; nitric oxide mediated signal transduction; ovulation from ovarian follicle; positive regulation of angiogenesis; positive regulation of apoptosis; positive regulation of guanylate cyclase activity; positive regulation of vasodilation; regulation of blood vessel size; regulation of sodium ion transport; regulation of systemic arterial blood pressure by endothelin; regulation of the force of heart contraction by chemical signal; removal of superoxide radicals; response to activity; response to amino acid stimulus; response to axon injury; response to corticosterone stimulus; response to cytokine stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to fructose stimulus; response to hyperoxia; response to hypoxia; response to lead ion; response to lipopolysaccharide; response to lipoprotein stimulus; response to mechanical stimulus; response to metal ion; response to organic cyclic substance; response to peptide hormone stimulus; retina development in camera-type eye; signal transduction; smooth muscle hyperplasia

NCBI Summary:enzyme that synthesizes Nitric oxide from L-arginine [RGD, Feb 2006]
UniProt Code:Q62600
NCBI GenInfo Identifier:46402488
NCBI Gene ID:24600
NCBI Accession:NP_068610.1
UniProt Secondary Accession:Q62600,O88672, O89041, Q62734, Q68GV6, Q75NE4,
UniProt Related Accession:Q62600
Molecular Weight:133,290 Da
NCBI Full Name:nitric oxide synthase, endothelial
NCBI Synonym Full Names:nitric oxide synthase 3
NCBI Official Symbol:Nos3  
NCBI Official Synonym Symbols:eNos  
NCBI Protein Information:nitric oxide synthase, endothelial
UniProt Protein Name:Nitric oxide synthase, endothelial
UniProt Synonym Protein Names:Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII
Protein Family:Nitric oxide synthase
UniProt Gene Name:Nos3  
UniProt Entry Name:NOS3_RAT

Related Products