The NOS1AP Polyclonal Antibody (PACO51750) is an essential tool for researchers studying NOS1AP, a protein involved in regulating nitric oxide synthase 1 (NOS1) activity and function. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting NOS1AP in human samples, making it ideal for use in Western blot applications.NOS1AP is known to play a critical role in cardiovascular function and disease, making it a valuable target for studies in cardiology and vascular biology. By targeting NOS1AP, researchers can gain insights into the mechanisms underlying cardiovascular disorders such as hypertension, heart failure, and arrhythmias.
Additionally, understanding the interactions between NOS1AP and NOS1 can provide valuable information for developing therapeutic strategies aimed at modulating nitric oxide signaling pathways.Overall, the NOS1AP Polyclonal Antibody offers researchers a reliable tool for investigating the roles and functions of NOS1AP in various biological processes, ultimately contributing to advancements in cardiovascular research and drug development.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO51750 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO51750 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human brain tissue using PACO51750 at dilution of 1:100.
Background:
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity).
Synonyms:
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (C-terminal PDZ ligand of neuronal nitric oxide synthase protein) (Nitric oxide synthase 1 adaptor protein), NOS1AP, CAPON KIAA0464
UniProt Protein Function:
NOS1AP: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 1q23.3Cellular Component: nuclear membrane; sarcoplasmic reticulum membrane; mitochondrion; perinuclear region of cytoplasm; T-tubule; caveola; Z disc; cytosol; nucleus; sarcolemmaMolecular Function: nitric-oxide synthase bindingBiological Process: regulation of apoptosis; regulation of nitric oxide biosynthetic process; positive regulation of nitric oxide biosynthetic process; chemical signal regulation of heart rate; positive regulation of nitric-oxide synthase activity; regulation of nitric-oxide synthase activityDisease: Qt Interval, Variation In
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]
