The NOS1 Polyclonal Antibody (CAB1485) is a valuable tool for researchers studying nitric oxide synthase 1 (NOS1), an enzyme involved in the production of nitric oxide, a crucial signaling molecule in various physiological processes. This antibody, produced in rabbits, is specifically designed for use in studies involving NOS1 in human samples and has been validated for Western blot applications.NOS1, also known as neuronal nitric oxide synthase, plays a key role in neurotransmission, vasodilation, and immune response modulation. Dysregulation of NOS1 activity has been implicated in various diseases such as neurodegenerative disorders, cardiovascular diseases, and inflammatory conditions.
By targeting NOS1 with this antibody, researchers can better understand its function and potentially develop novel therapeutic strategies for treating NOS1-related diseases.The NOS1 Polyclonal Antibody is an essential tool for any researcher interested in investigating the role of nitric oxide signaling in health and disease. Its high reactivity and specificity make it a reliable choice for detecting and studying NOS1 expression in a variety of cell types, making it a valuable asset in the fields of neuroscience, cardiovascular research, and immunology.
Product Name:
NOS1 Rabbit Polyclonal Antibody
SKU:
CAB1485
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NOS1 (NP_000611.1).
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4842
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of rat liver, using NOS1 antibody (CAB1485) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
