NOS1 Rabbit Polyclonal Antibody (CAB12795)
- SKU:
- CAB12795
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | NOS1 Rabbit Polyclonal Antibody |
SKU: | CAB12795 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human NOS1 (NP_000611.1). |
Sequence: | MEDH MFGV QQIQ PNVI SVRL FKRK VGGL GFLV KERV SKPP VIIS DLIR GGAA EQSG LIQA GDII LAVN GRPL VDLS YDSA LEVL RGIA SETH VVLI LRGP EGFT THLE TTFT GDGT PKTI RVTQ PLGP PTKA VDLS HQPP AGKE QPLA VDGA SGPG NGPQ HAYD DGQE AGSL PHAN GLAP |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:20 - 1:50 |
Synonyms: | NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS; NOS1 |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell projection, Peripheral membrane protein, dendritic spine, sarcolemma. |
Calculated MW: | 161kDa |
Observed MW: | 150kDa |
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 4842 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |