The Norrin Polyclonal Antibody (CAB1964) is a specialized tool for research involving Norrin, a protein involved in the Wnt signaling pathway and implicated in various cellular processes. The antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the Norrin protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential resource for studies in developmental biology, angiogenesis, and neurodegenerative diseases.Norrin, a secreted protein involved in angiogenesis and retinal vascular development, plays a crucial role in maintaining vascular integrity and promoting neuronal health.
Dysregulation of Norrin signaling has been linked to disorders such as familial exudative vitreoretinopathy (FEVR) and Norrie disease, highlighting its significance in both normal development and disease pathology. Investigating the function of Norrin with the use of this antibody can provide valuable insights into the underlying mechanisms of these conditions and potentially lead to the development of novel therapeutic strategies.
Product Name:
NDP Rabbit Polyclonal Antibody
SKU:
CAB1964
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-133 of human NDP (NP_000257.1).
This gene encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix. Mutations in this gene result in Norrie disease and X-linked exudative vitreoretinopathy.
Purification Method:
Affinity purification
Gene ID:
4693
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of PC-3, using NDP antibody (CAB1964) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
