The NOL6 Polyclonal Antibody (CAB14420) is a valuable tool for researchers studying NOL6, a protein associated with ribosome biogenesis and cell cycle progression. This antibody, generated in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the NOL6 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in molecular biology and cancer research.NOL6 plays a significant role in ribosome assembly and cellular proliferation, making it a crucial player in processes like RNA synthesis and protein translation.
Its involvement in these fundamental cellular pathways underscores its importance as a target for research into diseases such as cancer, where dysregulation of these processes can lead to uncontrolled cell growth and tumor formation. By elucidating the functions of NOL6, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic strategies.
Product Name:
NOL6 Rabbit Polyclonal Antibody
SKU:
CAB14420
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1032-1146 of human NOL6 (NP_075068.2).
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
65083
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NOL6 Rabbit pAb (CAB14420) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
