The Nodal Homolog Polyclonal Antibody (CAB9902) is a valuable tool for researchers studying the Nodal Homolog protein, which plays a key role in embryonic development and cell differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in applications such as Western blotting.The Nodal Homolog protein is a member of the TGF-beta superfamily and is essential for diverse cellular processes, including stem cell maintenance and tissue patterning during development. By targeting the Nodal Homolog protein, researchers can gain insights into its functions and signaling pathways in various cell types, offering new avenues for studies in developmental biology and regenerative medicine.
Understanding the role of Nodal Homolog in cellular processes is crucial for advancing our knowledge of embryonic development and tissue regeneration. The Nodal Homolog Polyclonal Antibody provides a reliable tool for investigating the functions and mechanisms of this important protein, opening up possibilities for therapeutic interventions in conditions related to developmental disorders and tissue repair.
Product Name:
NODAL Rabbit Polyclonal Antibody
SKU:
CAB9902
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 198-347 of human NODAL (NP_060525.3).
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. This protein is required for maintenance of human embryonic stem cell pluripotency and may play a role in human placental development. Mutations in this gene are associated with heterotaxy, a condition characterized by random orientation of visceral organs with respect to the left-right axis.
Purification Method:
Affinity purification
Gene ID:
4838
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NODAL antibody (CAB9902) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
